Some of the known quinazoline derivatives exhibited remarkable anti-cancer activity , , , , , , , however, search is continuously on to identify a more potent lead molecule as these molecules are developing resistance over a period. The present study was carried out with the aim of in-silico studies of anti cancer activity of some novel quinazoline derivatives lung cancer (cholinergic receptor nicotinic alpha 3) the compounds were screened using high throughput screening, and further subjected to induced fit docking studies. Keywords: anticancer activity, antimicrobial activity, quinazoline derivatives and amino acid derivatives 1 introduction quinazoline and their derivatives constitute an important class of heterocyclic compounds many of them show insecticidal, analgesic, antifungal, antibacterial, anticancer, anti-inflammatory activities.
Keywords: anticancer activity, antimicrobial activity, quinazoline derivatives and amino acid derivatives 1 introduction quinazoline and their derivatives constitute an important class of heterocyclic compounds synthesis, anticancer and anti-microbial characterization of some novel quinazoline derivatives. Quinazoline derivatives being considered as potent anti-inflammatory and anti-cancer agents, several new quinazoline derivatives 6a–6o were synthesized and screened for anti-inflammatory and anti-cancer activities the response of all the compounds to anti-inflammatory activity is moderate to poor, however, some of the compounds showed promising anti-cancer activity.
Synthesis of some novel quinazoline derivatives having anti-cancer activity glob j pharmaceu 002 sci 2017 3(2): 555610 the pasty mass obtained was diluted with 50ml of water and treated with aqueous sodium bicarbonate solution when the effervescence ceased, the precipitate obtained was filtered and washed with water. 273 m m ghorab and m s alsaid: anti-breast cancer activity of some novel quinoline derivatives, acta pharm 65 (2015) 271–283 mixture was cooled and the obtained product was crystallized from ethanol to give 1 (table i.
And quinazoline derivatives with aliphatic branch at 4-position of quinazoline core have moderate inhibitory activity for cyclin-dependent kinase chandregowda et al synthesized novel 4-anilinoquinazolines and evaluated their anti-cancer activity [ 1 . Synthesis of some novel quinazoline derivatives having anti-cancer activity glob j pharmaceu 003003 sci 2017 3(2): 555610 in 100µl of respective medium containing 10% fbs , at a plating density of 10,000 cells/well and incubated at 37 °c, 5%co 2, 95% air and 100% relative humidity for 24hrs prior to addition of samples.
All the derivatives 6 are screened for anti-inflammatory and anti-cancer activity against u937 leukemia cell lines some of the compounds exhibited promising anti-cancer activity with reference to standard drug etoposide.
4 e sumesh, v a airody and n s suchetha, synthesis and antimicrobial activities of novel quinoline derivatives carrying 1, 2, 4-triazole moiety, eur j med chem 44 (11) (2009) 4637–4647 doi: 101016/jejmech200906031 crossref google scholar 5 m.